Reds coach Richard Graham has named his team to tackle the Bulls in a Super Rugby clash in Pretoria on Saturday.
Lock Rob Simmons will play his first game of the season after recovering from a shoulder injury.
Simmons is one of six changes to the Reds starting team that faced the Rebels in Melbourne last week.
Simmons replaces James Horwill, who is serving a one-week suspension for striking.
Saia Faingaa returns to the starting team at hooker, with James Hanson moving to the bench, while an injury to Jake Schatz has forced a shuffle in the back row, with Curtis Browning starting at blindside flank and Adam Thomson shifting to No 8.
In the backline, an injury to Quade Cooper means Nick Frisby resumes the role of starting flyhalf. A recurrence of a calf injury has ruled out James OConnor, meaning Lachie Turner shifts to the wing and Karmichael Hunt returns to the starting line-up at fullback.
Graham has named six forwards and two backs on the bench, with Reds Elite Development Squad member Adam Korczyk getting a chance to make his debut.
Pretoria is always a fantastic challenge. The Bulls have made Loftus a fortress over the years and no Australian side has won there since 2007. That is a piece of history that the group would love to contest, Hill told the Reds official website .
Saturdays clash at Loftus Versfeld kicks off at 19:10.
15. Jesse Kriel, 14. Francois Hougaard, 13. JJ Engelbrecht, 12. Burger Odendaal, 11. Bjorn Basson, 10. Jacques-Louis Potgieter, 9. Rudy Paige, 8. Pierre Spies (captain), 7. Arno Botha, 6. Deon Stegmann, 5. Grant Hattingh, 4. Jacques du Plessis, 3. Trevor Nyakane, 2. Callie Visagie, 1. Dean Greyling
Substitutes: 16. Jaco Visagie, 17. Morne Mellett, 18. Marcel van der Merwe, 19. Flip van der Merwe, 20. Hanro Liebenberg, 21. Piet van Zyl, 22. Tian Schoeman, 23. Jurgen Visser
15 Karmichael Hunt, 14 Lachie Turner, 13 Samu Kerevi, 12 Anthony Faingaa, 11 Chris Feauai-Sautia, 10 Nick Frisby, 9 Will Genia, 8 Adam Thomson, 7 Liam Gill, 6 Curtis Browning, 5 Rob Simmons, 4 Dave McDuling, 3 Greg Holmes, 2 Saia Faingaa, 1 James Slipper
Substitutes: 16 James Hanson, 17 Ben Daley, 18 Sef Faagase, 19 Marco Kotze, 20 Tom Murday, 21 Adam Korczyk, 22 Ben Tapuai, 23 Chris Kuridrani